ChemFETs for Characterization of Anion Receptors

Detection of anions in aqueous environments is a key component to better understanding biological and environmental processes. Electrochemical sensors allow for the aqueous anion affinity evaluation of hydrophobic anion receptors. The receptors are integrated into the selective membrane of a chemically-sensitive field effect transistor (ChemFET)-based sensor, creating chemical selectivity that converts anion concentration to a measurable signal. The detection limit of each receptor towards a series of anions produces a quantitative anion affinity profile that can be compared to other receptors, providing key information on host-guest interactions and specific anion affinity.



Key Papers:

• Kuhl, G. M., Banning, D. H., Fargher, H. A., Davis, W. A., Howell, M. M., Zakharov, L. N., Pluth, M. D., Johnson, D. W., Benchmarking the placement of hydrosulfide in the Hofmeister series using a bambus[6]uril-based ChemFET sensor. Chem. Sci., 2023, 14, 10273–10279.

• H. Banning, D.; M. Kuhl, G.; M. Howell, M.; W. Johnson, D. Evaluating Impacts of Bambusuril Pocket Size and Sterics on Anion Binding Trends Using ChemFET Sensors. Org. Biomol. Chem. 2024, 22, 269–27.